Imatinib Brand Name– Gleevec
What is Imatinib
Imatinib is an oral BCR-ABL tyrosine kinase inhibitor.
It is indicated for the treatment of adults and pediatric patients with newly diagnosed chronic-phase Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML); chronic-phase, accelerated-phase, or myeloid or lymphoid blast-phase Ph+ CML after failure of interferon-alfa therapy; relapsed or refractory Ph+ acute lymphoblastic leukemia (ALL); myelodysplastic/myeloproliferative diseases associated with platelet-derived growth factor receptor; aggressive systemic mastocytosis without the D816V c-Kit mutation or with c-Kit mutational status unknown; and hypereosinophilic syndrome and/or chronic eosinophilic leukemia.
It is also indicated for the treatment of unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans; Kit (CD117)-positive unresectable and/or metastatic malignant gastrointestinal stromal tumors; and in pediatric patients 1 year of age and older with newly diagnosed Ph+ ALL in combination with chemotherapy.
Severe myelosuppression, congestive heart failure, and hepatotoxicity have been reported.
Indications
- acute lymphocytic leukemia (ALL)
- chronic eosinophilic leukemia (CEL)
- chronic myelogenous leukemia (CML)
- dermatofibrosarcoma protuberans
- desmoid tumor
- gastrointestinal stromal tumors (GIST)
- hypereosinophilic syndrome
- myelodysplastic syndrome (MDS)
- systemic mastocytosis
For the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML)
NOTE: The FDA has designated imatinib as an orphan drug for the treatment of CML.
Side Effects
- abdominal pain
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- alopecia
- alopecia
- anaphylactic shock
- anasarca
- anemia
- anemia
- angina
- angioedema
- anorexia
- anorexia
- anxiety
- anxiety
- aplastic anemia
- appetite stimulation
- arrhythmia exacerbation
- arthralgia
- arthralgia
- ascites
- asthenia
- asthenia
- atrial fibrillation
- avascular necrosis
- back pain
- back pain
- bleeding
- bleeding
- blepharitis
- blurred vision
- blurred vision
- bone pain
- bone pain
- breast enlargement
- bullous rash
- cardiac arrest
- cardiac tamponade
- cataracts
- cerebral edema
- cheilitis
- chest pain (unspecified)
- chest pain (unspecified)
- chills
- chills
- clastogenesis
- colitis
- confusion
- conjunctivitis
- constipation
- constipation
- cough
- cough
- dehydration
- depression
- depression
- diarrhea
- diarrhea
- dizziness
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspepsia
- dyspepsia
- dysphagia
- dyspnea
- dyspnea
- ecchymosis
- edema
- edema
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- eructation
- erythema
- erythema multiforme
- esophagitis
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- flatulence
- flatulence
- fluid retention
- fluid retention
- flushing
- folliculitis
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI obstruction
- GI perforation
- gout
- growth inhibition
- gynecomastia
- headache
- headache
- hearing loss
- heart failure
- hematemesis
- hematoma
- hematuria
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperamylasemia
- hyperbilirubinemia
- hyperbilirubinemia
- hypercalcemia
- hyperglycemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypertension
- hypertension
- hyperuricemia
- hypoalbuminemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypophosphatemia
- hypotension
- hypothyroidism
- hypoxia
- ileus
- impotence (erectile dysfunction)
- increased intracranial pressure
- increased urinary frequency
- infection
- infection
- influenza
- influenza
- insomnia
- insomnia
- intracranial bleeding
- jaundice
- lacrimation
- lethargy
- lethargy
- leukopenia
- leukopenia
- libido decrease
- lichen planus-like eruption
- lymphadenopathy
- lymphopenia
- lymphopenia
- macular edema
- malaise
- malaise
- melena
- memory impairment
- menorrhagia
- menstrual irregularity
- migraine
- muscle cramps
- muscle cramps
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- myalgia
- myocardial infarction
- myopathy
- nail discoloration
- nausea
- nausea
- nephrotoxicity
- neutropenia
- neutropenia
- night sweats
- night sweats
- ocular hemorrhage
- ocular irritation
- ocular pain
- optic neuritis
- oral ulceration
- osteonecrosis
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palpitations
- pancreatitis
- pancytopenia
- papilledema
- paresthesias
- paresthesias
- peptic ulcer
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral edema
- peripheral neuropathy
- petechiae
- pharyngitis
- pharyngitis
- photosensitivity
- pleural effusion
- pneumonitis
- pruritus
- pruritus
- pseudoporphyria
- psoriasis
- pulmonary edema
- pulmonary fibrosis
- pulmonary hypertension
- purpura
- rash
- rash
- renal failure (unspecified)
- restless legs syndrome (RLS)
- retinal hemorrhage
- rhabdomyolysis
- rhinitis
- sinus tachycardia
- sinusitis
- sinusitis
- skin hyperpigmentation
- skin hypopigmentation
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- subdural hematoma
- syncope
- testicular swelling
- thrombocytopenia
- thromboembolism
- thrombosis
- thrombotic microangiopathy
- tinnitus
- toxic epidermal necrolysis
- tremor
- tumor lysis syndrome (TLS)
- urticaria
- vasculitis
- vertigo
- vesicular rash
- vomiting
- vomiting
- weakness
- weight gain
- weight gain
- weight loss
- xerophthalmia
- xerosis
- xerosis
- xerostomia
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
- weight
Contraindications
- ascites
- bleeding
- bone marrow suppression
- breast-feeding
- cardiac disease
- children
- contraception requirements
- diabetes mellitus
- driving or operating machinery
- edema
- fungal infection
- geriatric
- GI bleeding
- growth inhibition
- heart failure
- hemochromatosis
- hepatic disease
- herpes infection
- hypertension
- immunosuppression
- infants
- infection
- jaundice
- neonates
- nephrotoxicity
- neutropenia
- pericardial effusion
- pleural effusion
- pregnancy
- pregnancy testing
- pulmonary edema
- renal disease
- renal impairment
- reproductive risk
- thrombocytopenia
- vaccination
- varicella
- ventricular dysfunction
- viral infection
Interactions
- Abciximab
- Abemaciclib
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alpha interferons
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Antithrombin III
- Antithymocyte Globulin
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Artesunate
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Bacillus Calmette-Guerin Vaccine, BCG
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bepridil
- Bicalutamide
- Boceprevir
- Bortezomib
- Bosutinib
- Brexpiprazole
- Brigatinib
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Ceritinib
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cilostazol
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclophosphamide
- Cyclosporine
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- Daclatasvir
- Dalteparin
- Danaparoid
- Dapagliflozin; Saxagliptin
- Dapsone
- Darifenacin
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- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Desipramine
- Desirudin
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
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- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Disopyramide
- Docetaxel
- Dofetilide
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Drospirenone; Estradiol
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- Dutasteride; Tamsulosin
- Duvelisib
- Echinacea
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encainide
- Encorafenib
- Enoxaparin
- Entrectinib
- Enzalutamide
- Eplerenone
- Eptifibatide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
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- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estropipate
- Eszopiclone
- Ethinyl Estradiol; Etonogestrel
- Etodolac
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Felodipine
- Fenoprofen
- Fentanyl
- Fesoterodine
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flurbiprofen
- Fluvastatin
- Fondaparinux
- food
- Fostamatinib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Ifosfamide
- Imipramine
- Indomethacin
- Influenza Virus Vaccine
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Intranasal Influenza Vaccine
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobupivacaine
- Levomethadyl
- Lidocaine
- Lidocaine; Prilocaine
- Live Vaccines
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Maprotiline
- Maraviroc
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Mephobarbital
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Methamphetamine
- Methohexital
- Methylergonovine
- Methysergide
- Metoprolol
- Mexiletine
- Midazolam
- Mifepristone
- Mitotane
- Nabumetone
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Nortriptyline
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osimertinib
- Oxaprozin
- Oxybutynin
- Oxycodone
- Paclitaxel
- Paricalcitol
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Pemigatinib
- Pentobarbital
- Pentosan
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phentermine; Topiramate
- Pimozide
- Piroxicam
- Ponatinib
- Porfimer
- Posaconazole
- Prednisone
- Primidone
- Propafenone
- Propoxyphene
- Propranolol
- Protease inhibitors
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Ramelteon
- Ranolazine
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
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- Rifamycins
- Rifapentine
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- Rimegepant
- Rivaroxaban
- Rolapitant
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- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Rufinamide
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- Secobarbital
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- Selpercatinib
- Selumetinib
- Sertraline
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulindac
- Suvorexant
- Tacrolimus
- Tadalafil
- Tafamidis
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- Tasimelteon
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- Tedizolid
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- Telithromycin
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- Terbinafine
- Tezacaftor; Ivacaftor
- Thiopental
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- Thyroid hormones
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- Topiramate
- Tramadol
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- Vinorelbine
- Vorapaxar
- Voriconazole
- Warfarin
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- Zanubrutinib
- Ziprasidone
- Zolpidem
