Iloperidone Brand Name– Fanapt
What is Iloperidone
Iloperidone is an oral atypical antipsychotic belonging to the benzisoxazole/benzoisothiazol derivatives class.
Iloperidone is used for the acute and maintenance treatment of schizophrenia in adult patients. In a long-term study, iloperidone was effective in delaying time to relapse in patients with schizophrenia who were stabilized on doses ranging from 8 mg/day to 24 mg/day.
Both CYP2D6 and CYP3A4 are involved in iloperidone metabolism; therefore, clinically significant drug interactions may occur with CYP2D6 or CYP3A4 inhibitors.
In clinical trials, iloperidone was associated with QTc prolongation, an effect that was enhanced during concurrent use of potent CYP2D6 or CYP3A4 inhibitors.
Due to the possibility of arrhythmias and sudden death associated with QTc prolongation, consideration should be given to the use of other treatment options prior to iloperidone administration.
As with all antipsychotics, iloperidone carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis.
Indications
- behavioral or psychological symptoms of dementia
- schizophrenia
For the treatment of schizophrenia
Side Effects
- agranulocytosis
- akathisia
- amenorrhea
- amnesia
- anaphylactoid reactions
- anemia
- angioedema
- apnea
- appetite stimulation
- arrhythmia exacerbation
- arthralgia
- AV block
- blepharedema
- blepharitis
- blurred vision
- bronchospasm
- cataracts
- cholelithiasis
- confusion
- conjunctivitis
- dehydration
- delirium
- depression
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- drowsiness
- dyskinesia
- dyspnea
- dystonic reaction
- dysuria
- edema
- ejaculation dysfunction
- emotional lability
- epistaxis
- esophagitis
- fatigue
- fecal incontinence
- fluid retention
- galactorrhea
- gastritis
- gynecomastia
- heart failure
- hostility
- hypercholesterolemia
- hyperemia
- hyperglycemia
- hyperlipidemia
- hyperprolactinemia
- hypersalivation
- hyperthermia
- hypertriglyceridemia
- hypokalemia
- hyponatremia
- hypotension
- hypothyroidism
- impotence (erectile dysfunction)
- impulse control symptoms
- increased urinary frequency
- infection
- lethargy
- leukopenia
- libido decrease
- mania
- mastalgia
- menorrhagia
- menstrual irregularity
- myalgia
- nasal congestion
- nasal dryness
- nausea
- nephrolithiasis
- neuroleptic malignant syndrome
- neutropenia
- nystagmus
- ocular inflammation
- oral ulceration
- orgasm dysfunction
- orthostatic hypotension
- palpitations
- paranoia
- paresthesias
- peptic ulcer
- polydipsia
- priapism
- prostatitis
- pruritus
- pseudoparkinsonism
- QT prolongation
- rash
- renal failure (unspecified)
- restless legs syndrome (RLS)
- restlessness
- rhinorrhea
- seizures
- SIADH
- sinus tachycardia
- stomatitis
- stroke
- syncope
- tardive dyskinesia
- testicular pain
- tinnitus
- torticollis
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vertigo
- water intoxication
- weight gain
- weight loss
- xerophthalmia
- xerostomia
Monitoring Parameters
- AIMS assessment
- blood glucose
- CBC
- glycosylated hemoglobin A1c (HbA1c)
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine
- serum electrolytes
- serum lipid profile
- serum prolactin
- thyroid function tests (TFTs)
- weight
Contraindications
- abrupt discontinuation
- agranulocytosis
- ambient temperature increase
- apheresis
- AV block
- bradycardia
- breast cancer
- breast-feeding
- cardiomyopathy
- celiac disease
- cerebrovascular disease
- children
- CNS depression
- coadministration with other CNS depressants
- dehydration
- dementia
- diabetes mellitus
- diabetic ketoacidosis
- driving or operating machinery
- dysphagia
- ethanol ingestion
- females
- fever
- geriatric
- heart failure
- hematological disease
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hyperparathyroidism
- hyperprolactinemia
- hyperthermia
- hypertriglyceridemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- hypovolemia
- infants
- infertility
- leukopenia
- long QT syndrome
- myocardial infarction
- neonates
- neurological disease
- neutropenia
- obesity
- orthostatic hypotension
- Parkinson’s disease
- pheochromocytoma
- poor metabolizers
- pregnancy
- pregnancy testing
- priapism
- QT prolongation
- rheumatoid arthritis
- seizure disorder
- seizures
- sickle cell disease
- sleep deprivation
- strenuous exercise
- stroke
- substance abuse
- suicidal ideation
- systemic lupus erythematosus (SLE)
- tardive dyskinesia
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Ambrisentan
- Amifampridine
- Amiloride
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- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
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- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
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- Chlorpheniramine; Hydrocodone
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