pregnancy associated APS

What is pregnancy associated APS? What are the criteria for pregnancy associated APS?

Patients can have primary or secondary pregnancy-associated APS. Those with primary disease do not have an associated autoimmune disease. Those with secondary APS can have numerous autoimmune diseases, although SLE is likely the most common.

  • • All patients must have: repeatedly positive aPLAs (twice separated by 12 weeks)
  • • Plus one of the following criteria:
    • • More than two consecutive unexplained first trimester pregnancy losses at <10 weeks of gestation with normal genetic evaluation.
    • • Preterm delivery (<34 weeks of gestation) due to eclampsia, severe preeclampsia, or placental insufficiency.
    • • At least one pregnancy loss at >10 weeks of gestation with normal fetal morphology.
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