Which patients with severe lupus nephritis are more likely to progress to ESRD

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Which patients with severe lupus nephritis are more likely to progress to end-stage renal disease (ESRD)?

  • • African-American (especially males) and Hispanic patients
  • • Lower socioeconomic status
  • • Poor medication compliance
  • • Comorbidities such as diabetes and HTN
  • • Failure to normalize serum creatinine or serum creatinine of >2mg/dL on therapy
  • • Failure to decrease proteinuria to <1 g/day within 6 months of starting treatment
  • • Renal biopsy evidence of high disease activity (cellular crescents) and chronicity (interstitial fibrosis)

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