Which of the antibodies measured in the ANA profile are useful to follow disease activity?
Antibodies to dsDNA often parallel disease activity in SLE. High titers of antibody to dsDNA are associated with lupus nephritis and increases in dsDNA antibody levels are frequently predictive of a flare of lupus activity. Other antibodies included in the ANA profile are markers of disease subsets but do not fluctuate with disease activity.
