Which leukodystrophy is virtually always associated with a particular endocrinologic deficiency

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Which leukodystrophy is virtually always associated with a particular endocrinologic deficiency? 

Adrenoleukodystrophy, an X-linked recessive disorder, is one of the peroxisomal disorders.

It is characterized by impaired beta-oxidation of the very long-chain (C26) fatty acids, leading to their accumulation.

In addition, patients also have adrenocortical insufficiency.

Onset is usually between 4 and 6 years of age.

An adult form of the disease called adrenomyeloneuropathy is characterized by progressive spastic paraparesis and peripheral neuropathy.

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