When should be Continuous Renal Replacement Therapy stopped

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When you should stop Continuous Renal Replacement Therapy?

Continuous Renal Replacement Therapy is usually stopped when evidence of kidney function recovery is seen in patients; most often, recovery is assessed by an improvement in urine output, a progressive decline in serum creatinine levels, and an improvement in measured creatinine clearance.

The precise level of kidney function required to allow the discontinuation of renal support has not been established; however, a creatinine clearance <12 mL/min could be inadequate to allow the discontinuation of renal replacement therapies.

In the ATN study, investigators discontinued renal support when the measured creatinine clearance was >20 mL/min, and it was left to the discretion of the treating physicians when the range fell between 12 and 20 mL/min.

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