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What types of glomerular lesions are seen with a chronic hepatitis B carrier state?
The most common glomerular pathology seen with HBV carriers is membranous nephropathy.
These patients can also develop an immune complex form of polyarteritis nodosa, membranoproliferative glomerulonephritis (MPGN), IgA nephropathy, and focal segmental glomerulosclerosis (FSGS).
Kidney Lesions Caused by Hepatitis B
HBeAg + HBsAg + | HBeAg − HBsAg + | HBeAg − HBsAg + | HBeAg − HBsAg + | |
|---|---|---|---|---|
| Kidney lesion | Membranous nephropathy | Membrano-proliferative glomerulonephritis | Polyarteritis Nodosa | IgA Nephropathy |
| Location of immune complexes | Sub-epithelial space | Sub-endothelial space | Blood vessel wall Medium size | Mesangium |
HBeAg , Hepatitis B e antigen; HBsAg , hepatitis B surface antigen; IgA , immunoglobulin A.
