What neoplasms are most likely to have musculoskeletal complaints upon presentation in childhood?
• Acute leukemia (especially acute lymphoblastic leukemia)—consider in any child with “painful” JIA.
• Neuroblastoma—70% of cases occur in children, with 85% of patients aged <5 years. Many have systemic symptoms.
• Ewing sarcoma—monoarticular pain.
• Lymphoma.
