What mutations can cause inherited frontotemporal dementia

What mutations can cause inherited frontotemporal dementia? 

Most cases are accounted for by mutations in the following genes:

  • MAPT/Tau
  • CHMP2B (involved in vacuolar sorting)
  • Progranulin (a neurotrophin-like factor)
  • TDP-43 (TAR DNA-binding protein of 43 kDa)
  • VCP (valosin-containing protein) and other more recently discovered mutations that comprise the multisystem proteinopathies consisting of FTD, Paget’s disease of bone, and inclusion body myopathy)
  • FUS (fused in sarcoma)
  • C9ORF72 (an intronic expanded hexanucleotide repeat)