What infectious agents trigger Reactive Arthritis

What infectious agents trigger Reactive Arthritis

UrogenitalChlamydia trachomatis a , Ureaplasma urealyticum b , Mycoplasma genitalium b
EnterogenicSalmonella a typhimurium, S. enteritidis, S. heidelberg, S. cholerae-suis
Shigella a flexneri, S. dysenteriae, S. sonnei
Yersinia a (especially O:3 and O:9), Y. pseudotuberculosis
Campylobacter a jejuni, C. Coli
Clostridium difficile b
Escherichia coli b , Diarrhogenic strains
Giardia lamblia b
RespiratoryChlamydia pneumoniae b
Group A beta-hemolytic Streptococcus b , c
ViralHuman immunodeficiency virus b , d
Multiple sources, case reports only eHelicobacter pylori
Vibrio parahaemolyticus
Mycobacterium bovis
Calmette-Guerin Bacillus
Klebsiella pneumonia
Strongyloides stercoralis

Note: In up to 40% of ReA patients, an infectious agent cannot be identified. Serologic tests especially for Chlamydia may identify a previous infection if cultures/PCR are negative.

a Common infections associated with ReA. Also, most common infections associated with HLA-B27-patients.

b Uncommon infections associated with ReA.

c Typically causes acute rheumatic fever, but has been described to cause ReA.

d ReA has occurred in the setting of HIV, but usually the virus is not directly associated and other pathogens may be implicated.

e Not full list but most prominent case reports.

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