Influence of HLA B27 on Reactive Arthritis

Influence of HLA B27 on Reactive Arthritis

How is Reactive Arthritis acquired? What is the influence of HLA B27?

Susceptibility to ReA may be conferred by the specific class I major histocompatibility antigen, HLA-B27. However, the development of ReA is strictly dependent on infection with certain organisms predominantly acquired through mucosal surfaces, enterogenic or urogenital (see Question 6). In hospital-based reports, HLA-B27 is present in 60% to 80% patients with ReA. These patients tend to have more severe arthritis, extraarticular manifestations, higher prevalence of sacroiliitis, and a protracted course. Notably in population-based studies, patients with ReA are less likely to be HLA-B27-positive (30% or less in some ethnic groups). These cases have a milder oligoarthritis with fewer systemic symptoms or extraarticular manifestations.

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