Potential factors involved in the pathogenesis of Reactive Arthritis

What are other potential factors involved in the pathogenesis of Reactive Arthritis?

Since patients who are HLA-B27-negative also develop ReA, other focus of investigations favors the role of microbial factors.

Some examples of these theories are: the ability of certain outer membrane proteins of some of the involved organisms ( Salmonella ) to stimulate specific interleukin (IL) responses (IL-17 and IL-23) in synovial cells; finding metabolically active particles ( Chlamydia ) in the synovial tissue of patients with chronic ReA; and alteration of the gut microbiota leading to an abnormal immune response.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top