Potential factors involved in the pathogenesis of Reactive Arthritis

What are other potential factors involved in the pathogenesis of Reactive Arthritis?

Since patients who are HLA-B27-negative also develop ReA, other focus of investigations favors the role of microbial factors.

Some examples of these theories are: the ability of certain outer membrane proteins of some of the involved organisms ( Salmonella ) to stimulate specific interleukin (IL) responses (IL-17 and IL-23) in synovial cells; finding metabolically active particles ( Chlamydia ) in the synovial tissue of patients with chronic ReA; and alteration of the gut microbiota leading to an abnormal immune response.


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