What happens in the synaptic cleft during neuromuscular transmission?
After ACh molecules bind to and activate AChRs, they are released back into the synaptic cleft.
Acetylcholinesterase (AChE) in the cleft then decomposes ACh into choline and acetic acid within a fraction of a millisecond, and choline reuptake by the presynaptic nerve terminal provides material for the synthesis of new ACh via the enzyme choline acetyl transferase.