Which drugs induces neuromuscular disorders

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Which drugs induces neuromuscular disorders? 

Peripheral neuropathy

  • Antimicrobial (isoniazid, ethambutol, dapsone, fluoroquinolones, metronidazole, antiretrovirals)
  • Antineoplastic (vinca alkaloids, platinum analogs, taxanes, sorafenib, thalidomide)
  • Antirheumatic (chloroquine, gold treatment, d -penicillamine)
  • Cardiovascular (amiodarone)
  • Other: colchicine

Neuromuscular junction (∗ aggravation or unmasking of myasthenia gravis)

  • Antimicrobial (aminoglycosides, fluoroquinolones, telithromycin)∗
  • Anticonvulsants (phenytoin)
  • Antirheumatic ( d -penicillamine, chloroquine)
  • Cardiovascular (quinidine, propranolol)∗
  • Psychotropic (lithium, chlorpromazine)∗
  • Muscle relaxants∗

Muscle (rhabdomyolysis,∗ neuroleptic malignant syndrome,∗∗ cramps/myalgias, † myopathy ‡ )

  • Amphotericin B∗
  • Antirheumatic (gold, † d -penicillamine, † steroid∗)
  • Psychotropic (lithium,∗ haloperidol,∗∗ fluphenazine∗∗)
  • Sedatives (barbiturates, diazepam)∗
  • Analgesics (heroin, morphine, salicylates, codeine)∗
  • Cardiovascular (statins, ‡ clofibrate,∗ labetalol, † captopril † )
  • Anesthetics (suxamethonium∗)

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