What gene is disrupted in the majority of sporadic cases of RCC

What gene is disrupted in the majority of sporadic cases of RCC?

The VHL gene is disrupted in up to 70% of sporadic cases of RCC. In approximately 50% of cases, somatic mutations occur, and in 10% to 20% of cases, the gene is hypermethylated.

A consequence of VHL mutation is upregulation of hypoxia-induced genes, leading to increased production of moieties such as vascular endothelial growth factor (VEGF). This, in turn, causes increased tumor angiogenesis.

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