Through what receptors does glutamate signal

Through what receptors does glutamate signal?

  • α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors—open directly and pass principally Na and K .
  • -methyl- d -aspartate (NMDA) receptors—require depolarization from AMPA receptor activation to pass Na, K, and Ca ions. If excessively stimulated, NMDA receptors may contribute to Ca 2+ -dependent processes that mediate neuronal injury.

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