Disorders that affect glutamate transport
Amyotrophic lateral sclerosis (ALS)
30% to 90% loss of EAAT2, the most abundant glutamate transporter in the brain, is seen in 60% to 70% of patients with sporadic ALS.
30% to 90% loss of EAAT2, the most abundant glutamate transporter in the brain, is seen in 60% to 70% of patients with sporadic ALS.