Symptoms of ST HUS

Symptoms of ST HUS

What are the presentation and clinical course of patients with ST HUS?

Patients often develop prodromal hemorrhagic diarrhea with associated abdominal pain after eating Shiga toxin–contaminated food. The kidney failure and other clinical manifestations (including thrombocytopenia and neurologic manifestations) develop after the diarrhea has begun to resolve. Among patients who develop Shiga toxin enteritis, 5% to 15% develop HUS. If neurologic abnormalities and hypertension occurred, they can persist even after the acute phase is over. End-stage kidney disease (ESKD) is rare.

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