Symptoms of minocycline induced lupus

Symptoms of minocycline induced lupus

What are the characteristic clinical features of minocycline induced lupus?

There have been multiple cases of DILE affecting young individuals (females > males, ages 14 to 31 years) after an average of 30 months (range, 6–72) of minocycline use for acne in doses of 50 to 200 mg/day. All patients have arthritis/arthralgias and most have a positive ANA (92%). Fever (38%), rash (20% to 30%), pleuritis/pneumonitis (10%), hepatitis (50% with elevated liver-associated enzymes), and anticardiolipin antibodies (33%) can be seen. Interestingly, only 10% to 15% have antihistone antibodies, but 67% to 85% have a positive pANCA with or without anti-MPO specificity.

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