Symptoms of minocycline induced lupus
What are the characteristic clinical features of minocycline induced lupus?
There have been multiple cases of DILE affecting young individuals (females > males, ages 14 to 31 years) after an average of 30 months (range, 6–72) of minocycline use for acne in doses of 50 to 200 mg/day. All patients have arthritis/arthralgias and most have a positive ANA (92%). Fever (38%), rash (20% to 30%), pleuritis/pneumonitis (10%), hepatitis (50% with elevated liver-associated enzymes), and anticardiolipin antibodies (33%) can be seen. Interestingly, only 10% to 15% have antihistone antibodies, but 67% to 85% have a positive pANCA with or without anti-MPO specificity.