What is a common clinical presentation of hypophysitis?
- Hypophysitis often presents as a mass lesion of the pituitary gland/stalk that simulates a pituitary adenoma, clinically and radiographically.
- Clinically, most patients present with headaches (> 70%), vision defects (> 40%), and variable degrees of anterior pituitary hormone deficiencies (50%–70%; most commonly gonadotroph (hypogonadism) > Corticotroph (adrenal insufficiency) > Thyrotroph (hypothyroidism).
- In addition, and unlike pituitary adenomas, primary and secondary hypophysitis commonly present with central DI (> 50%).