Symptoms of hypophysitis

What is a common clinical presentation of hypophysitis?

Hypophysitis often presents as a mass lesion of the pituitary gland/stalk that simulates a pituitary adenoma, clinically and radiographically. Clinically, most patients present with headaches (> 70%), vision defects (> 40%), and variable degrees of anterior pituitary hormone deficiencies (50%–70%; most commonly gonadotroph (hypogonadism) > Corticotroph (adrenal insufficiency) > Thyrotroph (hypothyroidism). In addition, and unlike pituitary adenomas, primary and secondary hypophysitis commonly present with central DI (> 50%).


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