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Symptoms of CRMO
- • Peak onset age 7 to 12 years, but can have adult-onset; females are two to four times more affected.
- • Many, but not all, have spontaneous resolution by adolescence.
- • Wide variability: unifocal or multifocal, monophasic, recurrent or unrelenting.
- • Focal bone pain (often insidious onset), often worse at night, with or without fever.
- • Most commonly affected bones include long bone metaphyses, vertebrae, clavicle, and pelvis; symmetric in 25% to 40%; risk of vertebral collapse with spinal involvement.