Suspected cause of idiopathic Osteonecrosis

What is the suspected cause of idiopathic Osteonecrosis?

ON without an identifiable cause accounts for 10% to 15% of all cases. Extensive analysis supports that many of these patients may have a hypercoagulable state as evidenced by elevated lipoprotein(a), low tissue plasminogen activator activity, and/or high plasminogen activator inhibitor levels. Others have been found to have high homocysteine levels, elevated antiphospholipid antibodies, low protein C or protein S levels, or the presence of Factor V Leiden.


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