Special dosing considerations for neonates and infants

Are there special dosing considerations for neonates and infants?

Yes. The pharmacokinetics and pharmacodynamics among neonates, preterm infants, and full term infants require special attention until 6 to 12 months of age. In general, analgesics are recommended for a shorter course of therapy. Dosing interval (time between doses) may be shorter or longer depending on how the drug is metabolized. Opioids should be dosed at one-fourth to one-third of the recommended weight-based starting dose for children. Subsequent doses must be titrated based on further evaluation of efficacy and monitoring for adverse effects.


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