Significance of silent and plurihormonal pituitary tumors

What is the significance of silent and plurihormonal pituitary tumors?

The diagnosis of a silent or a plurihormonal adenoma is important because of their typical aggressive behavior, high degrees of invasiveness, and high rates of recurrence. Patients with these tumors are typically refractory to standard treatments and often require repeat surgical resections and/or radiation treatments. In addition, a subset of silent tumors, particularly the silent ACTH- or GH-secreting tumors, may later progress to functionally-apparent disease, usually in association with tumor growth.

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