Nonfunctioning adenomas

What are the types of nonfunctioning adenomas?

Nonfunctional pituitary tumors are subtyped by immunohistochemical staining for the various pituitary hormones and the pituitary-specific transcription factors that delineate their pituitary cell lineages. NFAs constitute a heterogeneous group of tumors, including the following:

• Gonadotrophs the vast majority of cases [80%]—stain for LH-beta, FSH-beta, and/or alpha subunit and/or the transcription factor SF-1.

• Null cell tumors (negative immunoreactivity for both pituitary hormones and pituitary transcription factors).

• Silent adenomas (e.g., corticotroph adenomas—positive ACTH/T-Pit staining; somatotroph adenomas—positive GH/Pit-1 staining; or thyrotropinomas—positive thyroid-stimulating hormone [TSH]/ Pit-1 staining), but without clinical stigmata of hormone excess.

• Plurihormonal pituitary tumors (which stain for multiple pituitary hormones), although generally are not clinically evident.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top