What is the significance of an ANA with a nucleolar or centromere pattern?
The patient either has systemic sclerosis or has a high risk of developing this disease. The nucleolar pattern is seen in patients with diffuse disease, limited disease with anti-TH/TO, or polymyositis overlap (anti-PM-Scl). Anticentromere antibodies are associated with limited systemic sclerosis.
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ANA Profile AntibodiesANA Profile Antibodies dsDNARNPSMSS-ASS-BCentromereSystemic lupus erythematosus70%–80%30%30%40%15%RareRheumatoid arthritis(-)(-)(-)5%Rare(-)Mixed connective tissue disease(-)100% (high titer)(-)RareRareRareDiffuse systemic sclerosis(-)20% (low…
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