Significance of an ANA with a nucleolar or centromere pattern

What is the significance of an ANA with a nucleolar or centromere pattern?

The patient either has systemic sclerosis or has a high risk of developing this disease. The nucleolar pattern is seen in patients with diffuse disease, limited disease with anti-TH/TO, or polymyositis overlap (anti-PM-Scl). Anticentromere antibodies are associated with limited systemic sclerosis.

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