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Role of subcellular compartments of the canonical neuron in disease
How are the major subcellular compartments of the canonical neuron affected in disease?
Soma
site of pathological inclusions in neurodegenerative diseases
Dendrites
loss of dendritic spines in autism
Axon
susceptibility to shearing in traumatic brain injury, loss in Wallerian degeneration
Nodes of Ranvier
susceptibility to dysfunction in channelopathies
Myelin
loss in demyelinating diseases