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Role of prion hypothesis in neurological disease
Discuss the prion hypothesis and its relevance to neurological disease
- Altered prion proteins cause conformational changes in normal prion proteins.
- DNA and RNA are not required for infectivity.
- Human prion diseases classically include kuru, Creutzfeldt–Jakob disease (CJD), Gerstmann–Straüssler–Scheinker disease, fatal familial insomnia, and variant CJD.
- Neurodegenerative diseases (e.g., AD, PD, ALS) also feature self-perpetuating protein misfolding as pathogenic.
