Risk of thrombosis in a person with Antiphospholipid Antibodies

What is the risk of thrombosis in a person with Antiphospholipid Antibodies?

This depends on the clinical setting and of the aPL ab present. The presence of an LA increases the risk of thrombosis more than aCL/anti-β2GPI abs with the following odds ratios (ORs):

  • • Venous thromboembolism (OR 11) in patients aged <50 years.
  • • Stroke (OR 8.1) in patients aged <50 years.
  • • Fetal loss (OR 7.8).
  • • Thrombosis in an SLE patient (OR 5.6).

Pearl : patients who have all three aPL abs (“triple positives”) including LA, aCL abs, anti-β2GPI abs have the highest risk for thrombosis (OR 34.4).

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