What is the risk of thrombosis in a person with Antiphospholipid Antibodies?
This depends on the clinical setting and of the aPL ab present. The presence of an LA increases the risk of thrombosis more than aCL/anti-β2GPI abs with the following odds ratios (ORs):
- • Venous thromboembolism (OR 11) in patients aged <50 years.
- • Stroke (OR 8.1) in patients aged <50 years.
- • Fetal loss (OR 7.8).
- • Thrombosis in an SLE patient (OR 5.6).
Pearl : patients who have all three aPL abs (“triple positives”) including LA, aCL abs, anti-β2GPI abs have the highest risk for thrombosis (OR 34.4).