What are the Risk factors for the development of CMV infections post kidney transplantation
CMV is a member of the genus Herpesvirus and belongs to the family Herpesviridae. It is composed of a double-stranded DNA genome. Exposure to the virus, as indicated by immunoglobulin G anti-CMV antibodies, is present in more than two-thirds of donors and recipients prior to transplantation. CMV can be transmitted from the donor either by blood transfusions or by the transplanted kidney. Symptomatic CMV infection occurs in 20% to 60% of all transplant recipients and is a significant cause of morbidity and mortality.
Risk factors associated with the development of CMV infections post transplantation include lymphocyte-depleting induction therapy, high-dose MMF, and the absence of adequate antiviral prophylaxis.