Risk factors for Acute Tubular Necrosis

Risk factors for Acute Tubular Necrosis

What are the risk factors for the development of ATN?

Preexisting kidney disease with a decrease in GFR is the most significant risk factor for the development of Acute Tubular Necrosis.

Patients with diabetic nephropathy are at increased risk as compared to patients with nondiabetic kidney disease of equal severity.

Other factors that predispose to the development of Acute Tubular Necrosis include volume depletion and the use of pharmacologic agents that decrease kidney perfusion, particularly nonselective NSAIDs and selective cyclooxygenase-2 (COX-2) inhibitors.

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