Rheumatologic Manifestations of XLA

Rheumatologic Manifestations of XLA

ManifestationComments
Septic arthritisOccurs in 10% of patients
Extracellular, encapsulated bacteria ( S. pneumoniae H. influenzae ), S. aureus
Mycoplasma , particularly Ureaplasma urealyticum
Enteroviruses, particularly echovirus and coxsackie virus
Aseptic, possibly autoimmune, arthritisUsually mono- or oligoarticular; involves large joints; rarely destructive; rheumatoid factor and ANA absent. Occurs in 10% of patients
Dermatomyositis-like syndrome associated with progressive enterovirus (ECHO) CNS infectionPresents with rash and muscle weakness
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