Renal cell carcinoma – Interesting Facts

5 Interesting Facts of Renal cell carcinoma

1. The incidence of renal cell carcinoma has been steadily increasing with increased use of computerized tomography and other radiographic studies for diagnosing abdominal conditions.

2. Management of localized renal cell carcinoma largely entails surgical resection of the primary site and possibly adjacent lymph nodes.

3. Systemic therapy for metastatic renal cell carcinoma can be broadly divided into two categories: targeted therapy and immunotherapy. Targeted therapy entails agents that block the vascular endothelial growth factor signaling pathway, while novel immunotherapies target programmed death inhibitor-1, thereby decreasing T-cell anergy.

4. Vascular endothelial growth factor pathway inhibitors can cause hypertension and proteinuria.

5. Novel immunotherapeutic agents, such as programmed death-1 inhibitors, can cause a wide range of immune-related side effects, including autoimmune nephritis. Prompt initiation of steroids should occur if this is suspected.

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