Peptide receptor radioligand therapy

What is peptide receptor radioligand therapy?

Peptide receptor radioligand therapy takes advantage of the presence of somatostatin receptors on NETs to deliver radiopharmaceuticals directly to these tumors. NETs that show significant tracer uptake on somatostatin receptor–based functional imaging (68-Ga DOTATATE or In-111 pentetreotide) can subsequently be treated with one of several labeled analogues, such as 177-Lu DOTATATE, 90-Y edotreotide, or 90-Y DOTA tyr3-octreotide. Promising results in terms of symptom control have been reported in clinical trials.

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