Are there any medical therapies for nonfunctioning adenomas?
No. There are currently no effective, or U.S. Food and Drug Administration–approved, medical therapies for NFAs. Despite the presence of DA receptors on NFAs, the efficacy of DA agonists (i.e., bromocriptine and cabergoline) on tumor growth control varies widely. In addition, there is insufficient evidence to recommend the use of somatostatin receptor agonists (e.g., octreotide, lanreotide, pasireotide) for NFAs. Lastly, temozolomide (TMZ) can be considered in rare cases of very aggressive and malignant pituitary tumors.