Neuropsychiatric systemic lupus erythematosus (NPSLE)
What are the manifestations of central nervous system (CNS) involvement in SLE or neuropsychiatric systemic lupus erythematosus (NPSLE)?
Autoantibodies Associated with Neuropsychiatric Systemic Lupus Erythematosus
|Antiphospholipid||Focal neurologic manifestations like transverse myelitis or strokes|
|Ribosomal P||Psychiatric manifestations, especially psychosis|
|N-methyl-d-aspartate receptor||Cognitive dysfunction (dsDNA cross-react with glutamate receptor)|
|Anti-aquaporin 4/neuromyelitis optica||Transverse myelitis +/– optic neuritis, also see with SSA+ and Sjogren’s syndrome|