Neuropsychiatric systemic lupus erythematosus (NPSLE)

Neuropsychiatric systemic lupus erythematosus (NPSLE)

What are the manifestations of central nervous system (CNS) involvement in SLE or neuropsychiatric systemic lupus erythematosus (NPSLE)?

Autoantibodies Associated with Neuropsychiatric Systemic Lupus Erythematosus

AntibodyManifestation
AntiphospholipidFocal neurologic manifestations like transverse myelitis or strokes
AntineuronalDiffuse manifestations
Ribosomal PPsychiatric manifestations, especially psychosis
N-methyl-d-aspartate receptorCognitive dysfunction (dsDNA cross-react with glutamate receptor)
Anti-aquaporin 4/neuromyelitis opticaTransverse myelitis +/– optic neuritis, also see with SSA+ and Sjogren’s syndrome
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