What are the common neurologic manifestations in Mixed cryoglobulinemia?
A painful sensory polyneuropathy is the most common finding. It can be symmetric or asymmetric, and insidious or abrupt in onset. Motor involvement can also occur, typically months to years after the sensory neuropathy. Mononeuritis multiplex may also be seen. Neuropathy is thought to result from vasculitis of the vasa nervorum and is always painful. Central nervous system (CNS) involvement is exceedingly rare in MC, and other causes (e.g., atherosclerotic) should be explored if CNS symptoms occur.
