Modic changes of the vertebral endplates

What are Modic changes of the vertebral endplates?

These are MRI findings seen in the bone marrow adjacent to the vertebral endplates associated with degenerative disease in the lumbar spine.

  • • Modic type I change refers to a marrow edema–like pattern that histopathologically correlates with subchondral vascularized fibrous tissue and endplate fissures, and which is seen as low signal intensity on T1-weighted images and high signal intensity on fat-suppressed T2-weighted images relative to normal marrow signal.
  • • Modic type II change refers to a fatty marrow change seen as high signal intensity on T1-weighted images and as low signal intensity on fat-suppressed T2-weighted images relative to normal marrow signal.
  • • Modic type III change refers to subchondral sclerosis, which is seen as low signal intensity on both T1-weighted and T2-weighted images relative to normal marrow signal.
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