What are the major classes of inflammatory mediators that facilitate inflammation during the innate immune response?
Classes of Inflammatory Mediators that Facilitate Inflammation During the Innate Immune Response
| Vasoactive Mediators | Chemotactic Factors | Enzymes | Proinflammatory Cytokines |
|---|---|---|---|
| Histamine | Complement products (C3a, C5a) | Tryptase | IL-1, IL-6, IL-12, IL-17, IL-18, IL-23 |
| Arachidonic acid products (prostaglandins, leukotrienes) | Leukotriene B 4 | Chymase | TNFα |
| Platelet-activating factor | Platelet-activating factor | Type I interferons (e.g., IFNα), IFNγ | |
| Kinins | Chemokines (IL-8, other CXCLs) |
IFN, Interferon; IL, interleukin; TNF, tumor necrosis factor.
