Major classes of inflammatory mediators that facilitate inflammation during the innate immune response

What are the major classes of inflammatory mediators that facilitate inflammation during the innate immune response?

Classes of Inflammatory Mediators that Facilitate Inflammation During the Innate Immune Response

Vasoactive MediatorsChemotactic FactorsEnzymesProinflammatory Cytokines
HistamineComplement products (C3a, C5a)TryptaseIL-1, IL-6, IL-12, IL-17, IL-18, IL-23
Arachidonic acid products (prostaglandins, leukotrienes)Leukotriene B 4ChymaseTNFα
Platelet-activating factorPlatelet-activating factorType I interferons (e.g., IFNα), IFNγ
KininsChemokines (IL-8, other CXCLs)

IFN, Interferon; IL, interleukin; TNF, tumor necrosis factor.

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