Lab tests to evaluate hypercalcemia

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Lab tests to evaluate hypercalcemia

Which laboratory tests are helpful in the evaluation of hypercalcemia?

Serum PTH level will help distinguish a PTH-mediated from a non-PTH–mediated hypercalcemia.

In patients with normal kidney function, an elevated serum-intact PTH level will diagnose primary hyperparathyroidism in more than 90% of cases.

If serum PTH is low (usually <20 pg/mL or so), evaluation of PTH-rP, 25D and 1,25D, phosphorus, creatinine, vitamin A level, serum, and urine protein electrophoresis should be pursued based on the patient’s clinical and medication history.

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