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Lab findings in Mixed Connective Tissue Disease
What are the typical laboratory findings in a patient with Mixed Connective Tissue Disease?
Anemia is usually that of chronic disease. Coombs’ positivity is detected in up to 60% of patients, although overt hemolytic anemia is uncommon. Thrombocytopenia is uncommon. The sedimentation rate is usually elevated due to hypergammaglobulinemia. Hypocomplementemia is not associated with any particular clinical manifestation. Antibodies against other common nuclear antigens are rarely seen.
Laboratory Findings in Patients with Mixed Connective Tissue Disease
Abnormality | Frequency (%) |
---|---|
Anemia | 65–75 |
Leukopenia/lymphopenia | 57–75 |
Hypergammaglobulinemia | 80 |
Rheumatoid factor | 50 |
Antinuclear antibody (>1:1000) | 100 |
Anti-U1-RNP | 100 |
Hypocomplementemia | 2 |