Lab findings in Mixed Connective Tissue Disease

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Lab findings in Mixed Connective Tissue Disease

What are the typical laboratory findings in a patient with Mixed Connective Tissue Disease?

Anemia is usually that of chronic disease. Coombs’ positivity is detected in up to 60% of patients, although overt hemolytic anemia is uncommon. Thrombocytopenia is uncommon. The sedimentation rate is usually elevated due to hypergammaglobulinemia. Hypocomplementemia is not associated with any particular clinical manifestation. Antibodies against other common nuclear antigens are rarely seen.

Laboratory Findings in Patients with Mixed Connective Tissue Disease

AbnormalityFrequency (%)
Anemia65–75
Leukopenia/lymphopenia57–75
Hypergammaglobulinemia80
Rheumatoid factor50
Antinuclear antibody (>1:1000)100
Anti-U1-RNP100
Hypocomplementemia2

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