issues regarding hormone replacement therapy (HRT)
The Women’s Health Initiative study report in 2002 not only confirmed the efficacy of estrogen replacement therapy (ERT) and HRT for prevention of fractures but also confirmed a previously reported increased risk of breast cancer and cardiovascular events; following this report, the use of ERT and HRT significantly decreased. Currently ERT (women without an intact uterus) and HRT (women with an intact uterus) are recommended mainly for limited use for up to 3 years to treat postmenopausal hot flashes.
