Is there a role for plasmapheresis in recurrent focal and segmentary glomerulosclerosis

Is there a role for plasmapheresis in recurrent focal and segmentary glomerulosclerosis (FSGS)?

Yes, the mechanisms of recurrent FSGS and early detection of proteinuria after kidney transplantation are unclear, but the early reappearance of proteinuria suggests that a nondialyzable circulating factor that alters glomerular permeability may be present.

Removal of a circulating factor by immunoadsorption or plasma exchange may account for the remission of the disease in some patients.

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