Indications for immunosuppressive therapy in Systemic Sclerosis

What are the indications for immunosuppressive therapy in Systemic Sclerosis?

Immunosuppression in Systemic Sclerosis is typically reserved for those with progressive skin thickening, progressive ILD, inflammatory myopathy, or inflammatory arthritis.

As such, many patients with Systemic Sclerosis do not require immunosuppressive/immunomodulatory therapy.

For example, patients with centromere-positive lcSSc often may not require immunosuppression as their features tend to be more vascular in nature along with GI involvement.

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