Importance of evaluating biopsies for the extent of activity or chronicity

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What is the importance of evaluating biopsies for the extent of activity or chronicity?

Historically on a renal biopsy report, pathologists would provide a calculated score to represent disease activity and disease chronicity. However, more recent literature shows mixed predictive value of using such a score, and these calculations are no longer universally used. However, the identification of histologic changes that represent chronicity and activity may be helpful in contributing to the overall description of the renal biopsy. Evidence of fibrosis indicates chronic scarring disease, which may be less likely to respond to therapy.

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