ICPIs for treatment of thyroid cancer

Are any ICPIs being investigated for the treatment of thyroid cancer?

Small, ongoing clinical trials testing CTLA-4, PD-1, and PD-L1 inhibitors are underway in combination with other treatment modalities in patients with anaplastic, poorly differentiated, and recurrent differentiated thyroid cancers. In a recent case report, a patient with anaplastic thyroid cancer showing BRAF and PD-L1 positivity had complete clinical and radiographic remission 20 months after treatment with emurafenib and nivolumab.


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