How often do neurologic manifestations occur in Behcets disease
| Headaches (52%) | Cerebellar ataxia |
| Meningoencephalitis (28%) | Hemiplegia/paraparesis |
| Cranial nerve palsies (16%) | Pseudobulbar palsy |
| Seizures (13%) | Extrapyramidal signs |
Neurologic symptoms occur in 5% to 10% of patients, are more common in men, and tend to recur during flares of oral, genital, and joint lesions. Central nervous system (CNS) involvement, which may be life-threatening, is usually a late manifestation occurring from 1 to 7 years after the initial onset of disease. The most commonly involved region is the brainstem, but any area of the brain and spinal cord can be involved due to vasculitis or thrombosis. Intracranial hypertension, mostly resulting from dural sinus thrombosis, is seen in up to 20% of patients with neurologic disease and should be considered in patients with headache and ocular pain. Acute meningitis has been reported. Mortality of CNS Behçet’s disease is high (up to 40%).
