How is Whipple disease best treated

How is Whipple disease best treated? 

Initial treatment is ceftriaxone (or meropenem) for 2 weeks to ensure therapy of the CNS. Oral trimethoprim (TMP)–sulfamethoxazole (SMX) is subsequently used for more than 1 year. Tetracycline can be used in sulfa-allergic patients. Relapses can occur particularly in patients with CNS involvement (30%). These patients should be treated indefinitely with oral TMP/SMX.

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