How is Huntingtons disease treated
Unfortunately, to date no therapeutic intervention has been capable of halting the relentless progression of Huntingtons disease.
In the adult form, death occurs after a mean duration of 15 years, whereas in the juvenile variant the mean survival is 9 years.
In both observational and randomized controlled trials tetrabenazine has been shown to reduce Huntingtons disease chorea significantly.
Tetrabenazine is now considered the treatment of choice for chorea associated with HD as well as other choreas.
Other treatments include neuroleptics, which temporarily relieve both chorea and psychosis by interfering with dopaminergic transmission.
However, these drugs cause several side effects, including TD.
Selective serotonin reuptake inhibitors are the first-choice class of drugs for the treatment of depression in Huntingtons disease and also have been reported to be effective in the treatment of irritability and obsessive-compulsive behaviors.